TFAP4

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.^[5]

TFAP4
Identifiers
Aliases	TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4
External IDs	OMIM: 600743; MGI: 103239; HomoloGene: 2424; GeneCards: TFAP4; OMA:TFAP4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 4,257,186 bp[1] End 4,273,075 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.45 cM Start 4,362,525 bp[2] End 4,377,718 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell vena cava sural nerve ganglionic eminence cerebellar hemisphere lateral nuclear group of thalamus subthalamic nucleus nasal epithelium right hemisphere of cerebellum Top expressed in tail of embryo genital tubercle ventricular zone yolk sac epiblast female urethra muscle of thigh lip zygote embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity transcription coactivator activity histone deacetylase binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA binding E-box binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component transcription repressor complex nucleus mitochondrion Biological process negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity transcription, DNA-templated negative regulation of gene expression DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cellular response to dexamethasone stimulus negative regulation of DNA binding positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of apoptotic process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of mitotic cell cycle phase transition protein-containing complex assembly regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7023 83383 Ensembl ENSG00000090447 ENSMUSG00000005718 UniProt Q01664 Q9JIZ5 RefSeq (mRNA) NM_003223 NM_031182 RefSeq (protein) NP_003214 NP_112459 Location (UCSC) Chr 16: 4.26 – 4.27 Mb Chr 16: 4.36 – 4.38 Mb PubMed search [3] [4]
Wikidata
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Function

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.