TFDP1

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.^[5][6][7]

TFDP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AZE
Identifiers
Aliases	TFDP1, DP1, DRTF1, Dp-1, DILC, transcription factor Dp-1
External IDs	OMIM: 189902; MGI: 101934; HomoloGene: 38276; GeneCards: TFDP1; OMA:TFDP1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 113,584,721 bp[1] End 113,641,473 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 13,338,751 bp[2] End 13,378,448 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone ventricular zone bone marrow stromal cell of endometrium ganglionic eminence rectum olfactory zone of nasal mucosa mucosa of esophagus buccal mucosa cell Top expressed in granulocyte epiblast ventricular zone dermis tail of embryo abdominal wall fetal liver hematopoietic progenitor cell hair follicle genital tubercle primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein domain specific binding DNA-binding transcription factor activity protein binding transcription coactivator activity transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus mitochondrion nucleoplasm cytosol cytoplasm RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway cell cycle cell population proliferation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transcription, DNA-templated regulation of transcription involved in G1/S transition of mitotic cell cycle transcription by RNA polymerase II negative regulation of G0 to G1 transition positive regulation of transcription by RNA polymerase II negative regulation of fat cell proliferation epidermis development anoikis positive regulation of transcription, DNA-templated regulation of cell cycle regulation of DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7027 21781 Ensembl ENSG00000198176 ENSMUSG00000038482 UniProt Q14186 Q08639 RefSeq (mRNA) NM_007111 NM_001291765 NM_001291766 NM_001291768 NM_009361 NM_001358991 RefSeq (protein) NP_009042 NP_001278694 NP_001278695 NP_001278697 NP_033387 NP_001345920 Location (UCSC) Chr 13: 113.58 – 113.64 Mb Chr 8: 13.34 – 13.38 Mb PubMed search [3] [4]
Wikidata
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Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]^[7]

Interactions

TFDP1 has been shown to interact with:

• E2F1,^{[8][9][10][11]}
• E2F5,^[8][12] and
• P53.^[13]