TGIF2

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.^[5][6]

TGIF2
Identifiers
Aliases	TGIF2, TGFB induced factor homeobox 2
External IDs	OMIM: 607294; MGI: 1915299; HomoloGene: 32514; GeneCards: TGIF2; OMA:TGIF2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,573,488 bp[1] End 36,593,950 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,681,927 bp[2] End 156,697,490 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo ganglionic eminence sural nerve gonad buccal mucosa cell granulocyte right uterine tube testicle monocyte Top expressed in ventricular zone zygote phalanx of finger epiblast tail of embryo genital tubercle embryo thumb mandibular prominence maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II retina development in camera-type eye regulation of gastrulation positive regulation of neuron differentiation nodal signaling pathway transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60436 228839 Ensembl ENSG00000118707 ENSMUSG00000062175 UniProt Q9GZN2 Q8C0Y1 RefSeq (mRNA) NM_021809 NM_001199513 NM_001199514 NM_001199515 NM_001291124 NM_173396 RefSeq (protein) NP_001186442 NP_001186443 NP_001186444 NP_068581 NP_001278053 NP_775572 Location (UCSC) Chr 20: 36.57 – 36.59 Mb Chr 2: 156.68 – 156.7 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.^[6]