TH-PVP

TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,^[2] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.^{[3][4][5][6][7][8]}

TH-PVP

Clinical data
ATC code	None
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one
CAS Number	2304915-07-7 Y
PubChem CID	132989549
ChemSpider	82954253
UNII	S5MU9GV87C
Chemical and physical data
Formula	C19H27NO
Molar mass	285.431 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC(C(=O)C1=CC2=C(CCCC2)C=C1)N3CCCC3
InChI InChI=1S/C19H27NO/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17/h10-11,14,18H,2-9,12-13H2,1H3 Key:MMIKQWIZKBYLKZ-UHFFFAOYSA-N

Pharmacological studies in vitro showed it to inhibit reuptake of the monoamine neurotransmitters, with about 10-fold selectivity for serotonin over norepinephrine and dopamine, whereas the drug did not induce monoamine release.^[9] Despite its activity as a monoamine reuptake inhibitor, TH-PVP failed to produce stimulant effects in animals.^[10]

See also

• 3,4-Pr-PipVP
• 3-Me-PVP
• 4-Et-PVP
• 5-BPDi
• 6-APT
• EDMA
• Indapyrophenidone
• Naphyrone
• O-2390