THOC1

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.^[5][6]

THOC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXP
Identifiers
Aliases	THOC1, HPR1, P84, P84N5, THO complex 1
External IDs	OMIM: 606930; MGI: 1919668; HomoloGene: 38012; GeneCards: THOC1; OMA:THOC1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 214,520 bp[1] End 268,050 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 9,957,906 bp[2] End 9,995,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon cerebellar hemisphere right hemisphere of cerebellum right uterine tube anterior pituitary corpus callosum left ovary left lobe of thyroid gland body of pancreas tibial nerve Top expressed in cumulus cell spermatocyte tail of embryo Gonadal ridge epiblast external carotid artery abdominal wall primitive streak spermatid internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component cytoplasm transcription export complex nuclear matrix intercellular bridge THO complex THO complex part of transcription export complex nucleus nucleoplasm cytosol nuclear speck Biological process regulation of DNA recombination mRNA transport RNA processing regulation of transcription, DNA-templated negative regulation of DNA damage checkpoint mRNA processing regulation of DNA-templated transcription, elongation viral mRNA export from host cell nucleus transcription, DNA-templated positive regulation of DNA-templated transcription, elongation negative regulation of isotype switching to IgA isotypes RNA splicing replication fork processing signal transduction apoptotic process RNA export from nucleus mRNA export from nucleus mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9984 225160 Ensembl ENSG00000079134 ENSMUSG00000024287 UniProt Q96FV9 Q8R3N6 RefSeq (mRNA) NM_005131 NM_153552 RefSeq (protein) NP_005122 NP_705780 Location (UCSC) Chr 18: 0.21 – 0.27 Mb Chr 18: 9.96 – 10 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[6]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.^[7]