THOP1

Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.^[5][6]

THOP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S4B, 2O36
Identifiers
Aliases	THOP1, EP24.15, MEPD_HUMAN, MP78, TOP, thimet oligopeptidase 1
External IDs	OMIM: 601117; MGI: 1354165; HomoloGene: 55726; GeneCards: THOP1; OMA:THOP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,785,503 bp[1] End 2,815,807 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,905,869 bp[2] End 80,918,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right hemisphere of cerebellum right frontal lobe ventricular zone right lobe of liver apex of heart anterior pituitary muscle of thigh mucosa of transverse colon Top expressed in spermatid spermatocyte esophagus seminiferous tubule lip epiblast tail of embryo internal carotid artery embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity Cellular component cytoplasm mitochondrial intermembrane space cytosol Biological process proteolysis peptide metabolic process protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7064 50492 Ensembl ENSG00000172009 ENSMUSG00000004929 UniProt P52888 Q8C1A5 RefSeq (mRNA) NM_003249 NM_022653 RefSeq (protein) NP_003240 NP_073144 Location (UCSC) Chr 19: 2.79 – 2.82 Mb Chr 10: 80.91 – 80.92 Mb PubMed search [3] [4]
Wikidata
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