THRSP

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.^[5][6]

THRSP
Identifiers
Aliases	THRSP, LPGP1, Lpgp, S14, SPOT14, THRP, thyroid hormone responsive
External IDs	OMIM: 601926; MGI: 109126; HomoloGene: 2441; GeneCards: THRSP; OMA:THRSP - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 78,063,861 bp[1] End 78,068,351 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 97,062,145 bp[2] End 97,066,937 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm vena cava vulva right lobe of liver subcutaneous adipose tissue skin of hip lactiferous gland parotid gland synovial joint Top expressed in tunica adventitia of aorta brown adipose tissue white adipose tissue lactiferous gland subcutaneous adipose tissue intercostal muscle tunica media of zone of aorta left lobe of liver parotid gland mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity identical protein binding protein binding Cellular component cytoplasm nucleus nucleoplasm cytosol Biological process regulation of lipid biosynthetic process regulation of transcription, DNA-templated transcription, DNA-templated lipid metabolism regulation of triglyceride biosynthetic process carnitine shuttle response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7069 21835 Ensembl ENSG00000151365 ENSMUSG00000035686 UniProt Q92748 Q62264 RefSeq (mRNA) NM_003251 NM_009381 RefSeq (protein) NP_003242 NP_033407 Location (UCSC) Chr 11: 78.06 – 78.07 Mb Chr 7: 97.06 – 97.07 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.^[6]

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.^[7] Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.^[8]