TIMM13

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.^[5][6][7]

TIMM13
Identifiers
Aliases	TIMM13, TIM13, TIM13B, TIMM13A, TIMM13B, ppv1, translocase of inner mitochondrial membrane 13
External IDs	OMIM: 607383; MGI: 1353432; HomoloGene: 40846; GeneCards: TIMM13; OMA:TIMM13 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,425,625 bp[1] End 2,427,586 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,735,284 bp[2] End 80,736,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver prefrontal cortex muscle of thigh body of pancreas Top expressed in yolk sac proximal tubule right kidney neural tube white adipose tissue quadriceps femoris muscle adrenal gland blastocyst pancreas mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component mitochondrial intermembrane space protein transporter complex membrane mitochondrion fibrillar center mitochondrial inner membrane mitochondrial intermembrane space Biological process protein transport protein targeting to mitochondrion hearing protein insertion into mitochondrial inner membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26517 30055 Ensembl ENSG00000099800 ENSMUSG00000020219 UniProt Q9Y5L4 P62075 RefSeq (mRNA) NM_012458 NM_013895 RefSeq (protein) NP_036590 NP_038923 Location (UCSC) Chr 19: 2.43 – 2.43 Mb Chr 10: 80.74 – 80.74 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.^[7]

Interactions

TIMM13 has been shown to interact with TIMM8A.^[8][9]