TIMP4

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.^[5][6][7]

TIMP4
Identifiers
Aliases	TIMP4, TIMP metallopeptidase inhibitor 4, TIMP-4
External IDs	OMIM: 601915; MGI: 109125; HomoloGene: 37748; GeneCards: TIMP4; OMA:TIMP4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.2 Start 12,153,068 bp[1] End 12,158,912 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 53.29 cM Start 115,218,853 bp[2] End 115,229,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in abdominal fat subcutaneous adipose tissue thoracic aorta left coronary artery ascending aorta apex of heart synovial joint right hemisphere of cerebellum Descending thoracic aorta popliteal artery Top expressed in interventricular septum white adipose tissue lobe of cerebellum cerebellar vermis lumbar subsegment of spinal cord motor neuron deep cerebellar nuclei tunica media of zone of aorta substantia nigra brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity metal ion binding protease binding metalloendopeptidase inhibitor activity Cellular component sarcomere extracellular region extracellular space extracellular matrix Biological process Notch signaling pathway negative regulation of peptidase activity response to peptide hormone central nervous system development response to lipopolysaccharide ovulation cycle negative regulation of membrane protein ectodomain proteolysis negative regulation of catalytic activity negative regulation of endopeptidase activity response to hormone response to cytokine biological process response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7079 110595 Ensembl ENSG00000157150 ENSMUSG00000030317 UniProt Q99727 Q9JHB3 RefSeq (mRNA) NM_003256 NM_080639 NM_001356406 RefSeq (protein) NP_003247 NP_542370 NP_001343335 Location (UCSC) Chr 3: 12.15 – 12.16 Mb Chr 6: 115.22 – 115.23 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.^[7]

Interactions

TIMP4 has been shown to interact with MMP2.^[8][9]

See also

• TIMP1, TIMP2, TIMP3