TINF2

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.^[5][6] TINF2 is a component of the shelterin protein complex found at the end of telomeres.^[7]

TINF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BQO, 3BU8
Identifiers
Aliases	TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
External IDs	OMIM: 604319; MGI: 107246; HomoloGene: 8264; GeneCards: TINF2; OMA:TINF2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,239,643 bp[1] End 24,242,674 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,912,146 bp[2] End 55,919,277 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right adrenal gland right adrenal cortex left adrenal gland monocyte left adrenal cortex bone marrow cells blood tonsil spleen Top expressed in primary oocyte secondary oocyte primitive streak zygote epiblast seminiferous tubule spermatocyte tail of embryo granulocyte somite More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding telomeric DNA binding protein binding Cellular component nuclear telomere cap complex nuclear matrix perinucleolar chromocenter nucleoplasm chromosome shelterin complex telomere nucleus nuclear body Biological process protein localization to chromosome, telomeric region negative regulation of epithelial cell proliferation telomere assembly negative regulation of protein ADP-ribosylation telomere capping negative regulation of telomere maintenance via telomerase regulation of telomere maintenance via telomere lengthening Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26277 28113 Ensembl ENSG00000092330 ENSG00000284915 ENSMUSG00000007589 UniProt Q9BSI4 Q9QXG9 Q8K1K3 RefSeq (mRNA) NM_001099274 NM_012461 NM_001363668 NM_145705 RefSeq (protein) NP_001092744 NP_036593 NP_001350597 NP_663751 Location (UCSC) Chr 14: 24.24 – 24.24 Mb Chr 14: 55.91 – 55.92 Mb PubMed search [3] [4]
Wikidata
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Interactions

TINF2 has been shown to interact with ACD,^[8][9] POT1^[8][9][10] and TERF1.^[5][9][11]