TIP39

Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.^[5][6]

PTH2
Identifiers
Aliases	PTH2, TIP39, parathyroid hormone 2
External IDs	OMIM: 608386; MGI: 2152297; HomoloGene: 14235; GeneCards: PTH2; OMA:PTH2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,422,419 bp[1] End 49,423,441 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,830,419 bp[2] End 44,831,262 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte rhombencephalon metencephalon cerebellum cerebellar cortex cerebellar hemisphere gonad right hemisphere of cerebellum sensory nervous system occipital lobe Top expressed in olfactory epithelium seminiferous tubule embryo tibiofemoral joint spermatid neural layer of retina lumbar spinal ganglion olfactory bulb spermatocyte artery More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 113091 114640 Ensembl ENSG00000142538 ENSMUSG00000038300 UniProt Q96A98 Q91W27 RefSeq (mRNA) NM_178449 NM_053256 RefSeq (protein) NP_848544 NP_444486 Location (UCSC) Chr 19: 49.42 – 49.42 Mb Chr 7: 44.83 – 44.83 Mb PubMed search [3] [4]
Wikidata
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TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM]^[6]

The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding ^[7]

Expression of TIP39 has been linked to social interaction in both zebrafish ^[8] and rats.^[9] In these species, mutations of TIP39 or its receptor lead to abnormal social behavior.^[10][11]