Tight junction protein ZO-2

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.^[5]

TJP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OSG, 3E17
Identifiers
Aliases	TJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2, FHCA1
External IDs	OMIM: 607709; MGI: 1341872; HomoloGene: 3541; GeneCards: TJP2; OMA:TJP2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.11 Start 69,121,264 bp[1] End 69,274,615 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 24,071,869 bp[2] End 24,202,394 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Descending thoracic aorta ascending aorta right coronary artery C1 segment right lung subcutaneous adipose tissue duodenum right lobe of liver right lobe of thyroid gland Top expressed in otic vesicle saccule otic placode vestibular membrane of cochlear duct Paneth cell sciatic nerve conjunctival fornix left lung lobe epithelium of stomach cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein domain specific binding guanylate kinase activity protein binding cadherin binding Cellular component membrane bicellular tight junction adherens junction plasma membrane cell junction nucleus cytosol nucleoplasm Biological process establishment of endothelial intestinal barrier hippo signaling regulation of membrane permeability intestinal absorption GMP metabolic process GDP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9414 21873 Ensembl ENSG00000119139 ENSMUSG00000024812 UniProt Q9UDY2 Q9Z0U1 RefSeq (mRNA) NM_001170414 NM_001170415 NM_001170416 NM_001170630 NM_004817 NM_201629 NM_001369870 NM_001369871 NM_001369872 NM_001369873 NM_001369874 NM_001369875 NM_001198985 NM_011597 NM_001360391 NM_001360392 NM_001376368 RefSeq (protein) NP_001163885 NP_001163886 NP_001163887 NP_004808 NP_963923 NP_001185914 NP_035727 NP_001347320 NP_001347321 Location (UCSC) Chr 9: 69.12 – 69.27 Mb Chr 19: 24.07 – 24.2 Mb PubMed search [3] [4]
Wikidata
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Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].^[6]

Interactions

Tight junction protein 2 has been shown to interact with tight junction protein 1,^[7][8][9] band 4.1,^[10] occludin^[7][8][11] and USP53.^[12]