TLE3

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.^[5][6]

TLE3
Identifiers
Aliases	TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
External IDs	OMIM: 600190; MGI: 104634; HomoloGene: 21059; GeneCards: TLE3; OMA:TLE3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 70,047,790 bp[1] End 70,098,176 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 61,279,648 bp[2] End 61,325,779 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood ganglionic eminence sural nerve ventricular zone skin of leg buccal mucosa cell right testis monocyte left testis skin of abdomen Top expressed in genital tubercle Rostral migratory stream tail of embryo granulocyte decidua ventricular zone hair follicle lacrimal gland intestinal villus molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription corepressor activity Cellular component nucleus nucleoplasm beta-catenin-TCF complex transcription regulator complex Biological process animal organ morphogenesis regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated signal transduction beta-catenin-TCF complex assembly negative regulation of canonical Wnt signaling pathway negative regulation of cold-induced thermogenesis negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7090 21887 Ensembl ENSG00000140332 ENSMUSG00000032280 UniProt Q04726 Q6PRX3 Q08122 RefSeq (mRNA) NM_001105192 NM_001282979 NM_001282980 NM_001282981 NM_001282982 NM_005078 NM_020908 NM_001083927 NM_001083928 NM_009389 RefSeq (protein) NP_001098662 NP_001269908 NP_001269909 NP_001269910 NP_001269911 NP_005069 NP_065959 NP_001269908.1 NP_001077396 NP_001077397 NP_033415 Location (UCSC) Chr 15: 70.05 – 70.1 Mb Chr 9: 61.28 – 61.33 Mb PubMed search [3] [4]
Wikidata
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TLE3 expression has been linked to higher survival rates for lung cancer patients.^[7]