TLX2

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.^[5][6]

TLX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A03
Identifiers
Aliases	TLX2, HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	OMIM: 604240; MGI: 1350935; HomoloGene: 7575; GeneCards: TLX2; OMA:TLX2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,513,463 bp[1] End 74,517,148 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.94 cM Start 83,045,305 bp[2] End 83,047,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad transverse colon mucosa of transverse colon muscle layer of sigmoid colon right testis left testis primary visual cortex rectum duodenum appendix Top expressed in lumbar spinal ganglion adrenal medulla autonomic nervous system glossopharyngeal ganglion parasympathetic nervous system female urethra male urethra autonomic ganglion sympathetic nervous system cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component cytoplasm nucleus cellular component Biological process multicellular organism development enteric nervous system development mesoderm formation regulation of transcription, DNA-templated negative regulation of dendrite morphogenesis transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3196 21909 Ensembl ENSG00000115297 ENSMUSG00000068327 UniProt O43763 Q61663 RefSeq (mRNA) NM_016170 NM_001534 NM_009392 RefSeq (protein) NP_057254 NP_033418 Location (UCSC) Chr 2: 74.51 – 74.52 Mb Chr 6: 83.05 – 83.05 Mb PubMed search [3] [4]
Wikidata
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Interactions

TLX2 has been shown to interact with YWHAH.^[7]