TM4SF1

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.^[5][6]

TM4SF1
Identifiers
Aliases	TM4SF1, H-L6, L6, M3S1, TAAL6, transmembrane 4 L six family member 1
External IDs	OMIM: 191155; MGI: 104678; HomoloGene: 7409; GeneCards: TM4SF1; OMA:TM4SF1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 149,369,022 bp[1] End 149,377,692 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 57,193,032 bp[2] End 57,209,409 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava parietal pleura cartilage tissue visceral pleura germinal epithelium epithelium of lactiferous gland lactiferous duct pericardium islet of Langerhans lower lobe of lung Top expressed in tunica media of zone of aorta endothelial cell of lymphatic vessel right lung lobe carotid body atrioventricular valve semi-lunar valve aortic valve ascending aorta endocardial cushion left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component integral component of plasma membrane membrane integral component of membrane Biological process biological process blastocyst formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4071 17112 Ensembl ENSG00000169908 ENSMUSG00000027800 UniProt P30408 Q64302 RefSeq (mRNA) NM_014220 NM_008536 NM_001355130 RefSeq (protein) NP_055035 NP_032562 NP_001342059 Location (UCSC) Chr 3: 149.37 – 149.38 Mb Chr 3: 57.19 – 57.21 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.^[6]

Marker gene for alveolar epithelial progenitors

TM4SF1 has been identified as a marker of Wnt-responsive alveolar epithelial progenitor cells, and a marker of alveolar repair in injured regions of the lungs.^[7] It has also been found hypomethylated and upregulated in asthma, with potential prognostic value (AUROC: 0.769).^[8]