TM4SF5

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.^[5][6]

TM4SF5
Identifiers
Aliases	TM4SF5, transmembrane 4 L six family member 5
External IDs	OMIM: 604657; MGI: 1922854; HomoloGene: 2947; GeneCards: TM4SF5; OMA:TM4SF5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,771,884 bp[1] End 4,783,213 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 70,396,070 bp[2] End 70,402,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right lobe of liver duodenum mucosa of ileum mucosa of transverse colon testicle gonad kidney tubule rectum human kidney Top expressed in duodenum jejunum migratory enteric neural crest cell crypt of lieberkuhn of small intestine ileum vestibular membrane of cochlear duct intestinal epithelium epithelium of small intestine mucous cell of stomach intestinal villus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 9032 75604 Ensembl ENSG00000142484 ENSMUSG00000018919 UniProt O14894 n/a RefSeq (mRNA) NM_003963 NM_029360 RefSeq (protein) NP_003954 n/a Location (UCSC) Chr 17: 4.77 – 4.78 Mb Chr 11: 70.4 – 70.4 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.^[6]