TMED10

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.^[4][5][6]

TMED10
Identifiers
Aliases	TMED10, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10
External IDs	OMIM: 605406; MGI: 3782198; HomoloGene: 4972; GeneCards: TMED10; OMA:TMED10 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,131,469 bp[1] End 75,176,612 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland islet of Langerhans stromal cell of endometrium germinal epithelium beta cell corpus epididymis caput epididymis olfactory zone of nasal mucosa mucosa of sigmoid colon skin of thigh n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding syntaxin binding protein-containing complex binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane secretory granule membrane membrane intracellular membrane-bounded organelle melanosome Golgi membrane cis-Golgi network plasma membrane transport vesicle membrane transport vesicle zymogen granule membrane endoplasmic reticulum ER to Golgi transport vesicle membrane trans-Golgi network transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane gamma-secretase complex cytoplasmic vesicle COPI-coated vesicle endoplasmic reticulum-Golgi intermediate compartment COPII-coated ER to Golgi transport vesicle Biological process regulation of amyloid-beta formation Golgi organization kidney development COPI coating of Golgi vesicle vesicle targeting, to, from or within Golgi COPI-coated vesicle budding endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating response to alkaloid protein complex oligomerization vesicle cargo loading protein transport regulated exocytosis intracellular protein transport vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10972 100042773 Ensembl ENSG00000170348 ENSMUSG00000114251 UniProt P49755 n/a RefSeq (mRNA) NM_006827 XM_036158265 RefSeq (protein) NP_006818 n/a Location (UCSC) Chr 14: 75.13 – 75.18 Mb n/a PubMed search [2] [3]
Wikidata
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This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.^[6]