TMEM123

Porimin is a protein that in humans is encoded by the TMEM123 gene.^[5][6]

TMEM123
Identifiers
Aliases	TMEM123, KCT3, PORIMIN, PORMIN, transmembrane protein 123
External IDs	OMIM: 606356; MGI: 1919179; HomoloGene: 14177; GeneCards: TMEM123; OMA:TMEM123 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.2 Start 102,396,332 bp[1] End 102,470,384 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 7,764,042 bp[2] End 7,794,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of nasopharynx olfactory zone of nasal mucosa human penis skin of thigh germinal epithelium epithelium of colon tonsil lymph node ganglionic eminence Top expressed in mesenteric lymph nodes transitional epithelium of urinary bladder spleen seminal vesicula decidua superior surface of tongue conjunctival fornix tunica media of zone of aorta corneal stroma blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor activity Cellular component integral component of membrane membrane external side of plasma membrane cytoplasmic vesicle Biological process oncosis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114908 71929 Ensembl ENSG00000152558 ENSMUSG00000050912 UniProt Q8N131 Q91Z22 RefSeq (mRNA) NM_052932 NM_133739 RefSeq (protein) NP_443164 NP_598500 Location (UCSC) Chr 11: 102.4 – 102.47 Mb Chr 9: 7.76 – 7.79 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.

Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.

Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.^[6]