TMEM66

SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66).^[5][6]

SARAF
Identifiers
Aliases	SARAF, FOAP-7, TMEM66, XTP3, HSPC035, store-operated calcium entry associated regulatory factor
External IDs	OMIM: 614768; MGI: 1915137; HomoloGene: 9398; GeneCards: SARAF; OMA:SARAF - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 30,063,003 bp[1] End 30,083,208 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 34,621,717 bp[2] End 34,637,999 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium endothelial cell corpus epididymis sperm Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleus Top expressed in olfactory epithelium median eminence arcuate nucleus paraventricular nucleus of hypothalamus supraoptic nucleus seminal vesicula central gray substance of midbrain dorsomedial hypothalamic nucleus parotid gland islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane membrane endoplasmic reticulum endoplasmic reticulum-plasma membrane contact site Biological process ion transport regulation of store-operated calcium entry calcium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51669 67887 Ensembl ENSG00000133872 ENSMUSG00000031532 UniProt Q96BY9 Q8R3Q0 RefSeq (mRNA) NM_016127 NM_001284239 NM_026432 RefSeq (protein) NP_001271168 NP_057211 NP_080708 Location (UCSC) Chr 8: 30.06 – 30.08 Mb Chr 8: 34.62 – 34.64 Mb PubMed search [3] [4]
Wikidata
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Function

SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca²⁺ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.^[7]