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TMUB2
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[4][5][6]
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Gene
TMUB2 maps on the human chromosome 17, at locus 17q21.31.[6] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[7] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[8]
Expression
TMUB2 is likely ubiquitously expressed throughout the human body.[9] It has a high expression level that is 2.9 times higher than other human genes.[10][11]
Protein
The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[12] These will likely vary in orthologs.
Homology
Paralogs
TMUB1 is the only paralog of TMUB2.[13][14] These proteins share a 38% identity and 51% similarity.[15]
Orthologs
The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[15]
*Limited Query Coverage
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Protein Interactions
In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[16][17][18][19] Other proposed interactions include BCL2L13 (BCL2-like 13),[20] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[20] and UBQLN1 (Ubiquilin-1).[20][21][22]
References
Further reading
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