TNFAIP1

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.^[5][6][7]

TNFAIP1
Identifiers
Aliases	TNFAIP1, B12, B61, BTBD34, EDP1, hBACURD2, TNF alpha induced protein 1
External IDs	OMIM: 191161; MGI: 104961; HomoloGene: 22519; GeneCards: TNFAIP1; OMA:TNFAIP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,335,602 bp[1] End 28,347,009 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,413,676 bp[2] End 78,427,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle spleen upper lobe of left lung left ventricle right lobe of liver gallbladder right lung islet of Langerhans body of pancreas smooth muscle tissue Top expressed in Paneth cell endocardial cushion endothelial cell of lymphatic vessel fossa condyle ciliary body medullary collecting duct retinal pigment epithelium atrioventricular junction internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding protein domain specific binding identical protein binding Cellular component cytoplasm endosome Cul3-RING ubiquitin ligase complex nucleolus nucleus Biological process positive regulation of DNA replication DNA replication negative regulation of Rho protein signal transduction protein homooligomerization cell migration protein ubiquitination immune response stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7126 21927 Ensembl ENSG00000109079 ENSMUSG00000017615 UniProt Q13829 O70479 RefSeq (mRNA) NM_021137 NM_001159392 NM_009395 RefSeq (protein) NP_066960 NP_001152864 NP_033421 Location (UCSC) Chr 17: 28.34 – 28.35 Mb Chr 11: 78.41 – 78.43 Mb PubMed search [3] [4]
Wikidata
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This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.^[7]