TNFAIP8L2

TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.^[5]

TNFAIP8L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3F4M
Identifiers
Aliases	TNFAIP8L2, TIPE2, TNF alpha induced protein 8 like 2
External IDs	OMIM: 612112; MGI: 1917019; HomoloGene: 56998; GeneCards: TNFAIP8L2; OMA:TNFAIP8L2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,156,649 bp[1] End 151,159,749 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,046,832 bp[2] End 95,049,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood mucosa of ileum spleen appendix lymph node gonad testicle trabecular bone Top expressed in granulocyte mesenteric lymph nodes blood stroma of bone marrow blastocyst spleen subcutaneous adipose tissue thymus jejunum morula More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm Biological process innate immune response negative regulation of T cell activation negative regulation of inflammatory response immune system process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79626 69769 Ensembl ENSG00000163154 ENSMUSG00000013707 UniProt Q6P589 Q9D8Y7 RefSeq (mRNA) NM_024575 NM_027206 RefSeq (protein) NP_078851 NP_081482 Location (UCSC) Chr 1: 151.16 – 151.16 Mb Chr 3: 95.05 – 95.05 Mb PubMed search [3] [4]
Wikidata
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Function

TNFAIP8L2 is a member of the TNFAIP8 (tumor necrosis factor-α-induced protein 8, or TIPE) family that function as transfer proteins for the second messenger lipids PIP2 and PIP3. The other three family members are TNFAIP8, TNFAIP8L1 and TNFAIP8L3.^[6]

Structure

The crystal structure of TIPE2 reveals that it contains a large, hydrophobic central cavity that is poised for cofactor binding.^[7]

Clinical significance

TIPE2 acts as a negative regulator of the immune system.^[5][8] It is down-regulated in patients with infectious and autoimmune diseases and also acts as a tumor suppressor in several types of cancer.^[9] Its knockout leads to leukocytosis and systemic inflammatory disorders in mice.^[6][10]