TNFSF12-TNFSF13

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.^[5]

TNFSF12-TNFSF13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4HT1
Identifiers
Aliases	TNFSF12-TNFSF13, TWE-PRIL, TNFSF12-TNFSF13 readthrough
External IDs	MGI: 3845075; HomoloGene: 123930; GeneCards: TNFSF12-TNFSF13; OMA:TNFSF12-TNFSF13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,549,099 bp[1] End 7,561,601 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,573,403 bp[2] End 69,586,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa granulocyte blood stromal cell of endometrium monocyte gastric mucosa subcutaneous adipose tissue right coronary artery renal cortex thoracic aorta Top expressed in neural layer of retina lung ovary quadriceps femoris muscle duodenum muscle tissue adrenal gland bone marrow right kidney muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein binding tumor necrosis factor receptor binding signaling receptor binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region perinuclear region of cytoplasm extracellular space Biological process cell differentiation positive regulation of endothelial cell proliferation positive regulation of protein catabolic process extrinsic apoptotic signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of angiogenesis multicellular organism development angiogenesis immune response apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway endothelial cell migration signal transduction apoptotic process regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 407977 619441 Ensembl ENSG00000248871 ENSMUSG00000018752 UniProt O43508 n/a RefSeq (mRNA) NM_172089 NM_001034097 NM_001034098 NM_001159503 RefSeq (protein) NP_003800 n/a Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.57 – 69.59 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.^[5]