TNIP1

TNFAIP3-interacting protein 1, also known as ABIN-1, is a protein that in humans is encoded by the TNIP1 gene.^[5][6][7]

TNIP1
Identifiers
Aliases	TNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDs	OMIM: 607714; MGI: 1926194; HomoloGene: 31355; GeneCards: TNIP1; OMA:TNIP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,029,945 bp[1] End 151,093,577 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 54,801,611 bp[2] End 54,853,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood muscle of thigh epithelium of colon apex of heart gastrocnemius muscle glutes bone marrow cell granulocyte cartilage tissue spleen Top expressed in decidua left colon temporal muscle granulocyte triceps brachii muscle muscle of thigh mesenteric lymph nodes sternocleidomastoid muscle jejunum pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mitogen-activated protein kinase binding identical protein binding polyubiquitin modification-dependent protein binding Cellular component intracellular anatomical structure nucleoplasm nucleus cytosol cytoplasm Biological process leukocyte cell-cell adhesion defense response glycoprotein biosynthetic process negative regulation of viral genome replication modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade positive regulation of inflammatory response inflammatory response protein biosynthesis negative regulation of ERK1 and ERK2 cascade MyD88-dependent toll-like receptor signaling pathway regulation of inflammatory response negative regulation of I-kappaB kinase/NF-kappaB signaling protein deubiquitination positive regulation of transcription by RNA polymerase II cellular response to lipopolysaccharide positive regulation of protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10318 57783 Ensembl ENSG00000145901 ENSMUSG00000020400 UniProt Q15025 Q9WUU8 RefSeq (mRNA) NM_001252385 NM_001252386 NM_001252390 NM_001252391 NM_001252392 NM_001252393 NM_001258454 NM_001258455 NM_001258456 NM_006058 NM_001364486 NM_001364487 NM_001199275 NM_001199276 NM_001271455 NM_001271456 NM_021327 RefSeq (protein) NP_001239314 NP_001239315 NP_001239319 NP_001239320 NP_001239321 NP_001239322 NP_001245383 NP_001245384 NP_001245385 NP_006049 NP_001351415 NP_001351416 NP_001186204 NP_001186205 NP_001258384 NP_001258385 NP_067302 Location (UCSC) Chr 5: 151.03 – 151.09 Mb Chr 11: 54.8 – 54.85 Mb PubMed search [3] [4]
Wikidata
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Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

• Systemic Sclerosis;^[8]
• Psoriasis;^[9]
• Psoriatic arthritis;^[10]
• Systemic Lupus Erythematosus^[11][12]
• Type-1 autoimmune hepatitis^[13]
• Lupus nephritis^[14]

TNIP1 dysfunction or deficiency contributes to hyperinflammarion and may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure.^[15]

Association with neurodegenerative diseases

A recent genome-wide association study (GWAS) has found that genetic variations in TNIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD).^[16]

Interactions

TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,^[17] and has been shown to interact with TNFAIP3,^[18] MAP3K1,^[19] and MAPK1.^[20]

Regulation

TNIP1 was shown to be part of a transcription module controlled by BCL3. BCL3 gen was found to be strongly associated with Aβ42 after conditioning for APOE and was found as upregulated in the brain of patients with LOAD.^[16]