Tankyrase 2

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.^[5]

TNKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y0I, 3KR7, 3KR8, 3MHJ, 3MHK, 3P0N, 3P0P, 3P0Q, 3TWQ, 3TWR, 3TWS, 3TWT, 3TWU, 3TWV, 3TWW, 3TWX, 3U9H, 3U9Y, 3UA9, 3W51, 4AVU, 4AVW, 4BFP, 4BJ9, 4BJB, 4BJC, 4BS4, 4BU3, 4BU5, 4BU6, 4BU7, 4BU8, 4BU9, 4BUA, 4BUD, 4BUE, 4BUF, 4BUI, 4BUS, 4BUT, 4BUU, 4BUV, 4BUW, 4BUX, 4BUY, 4HKI, 4HKK, 4HKN, 4HL5, 4HLF, 4HLG, 4HLH, 4HLK, 4HLM, 4HMH, 4HYF, 4IUE, 4J1Z, 4J21, 4J22, 4J3L, 4J3M, 4KZL, 4KZQ, 4KZU, 4L09, 4L0B, 4L0I, 4L0S, 4L0T, 4L0V, 4L10, 4L2F, 4L2G, 4L2K, 4L31, 4L32, 4L33, 4L34, 4M7B, 4PML, 4PNL, 4PNM, 4PNN, 4PNQ, 4PNR, 4PNS, 4PNT, 4TJU, 4TJW, 4TJY, 4TK0, 4TK5, 4TKF, 4TKG, 4TKI, 4UVL, 4UVN, 4UVO, 4UVP, 4UVS, 4UVT, 4UVU, 4UVV, 4UVW, 4UVX, 4UVY, 4UVZ, 4UX4, 4W5I, 5AKU, 5AKW, 5AL1, 5AL2, 5AL3, 5AL4, 5AL5, 5C5P, 5C5Q, 5C5R, 5ADT, 5ADS, 5ADQ, 5AEH, 5ADR, 4Z68, 5BXU, 4UI5, 4UFY, 4UI7, 4UI3, 4UI4, 4UFU, 4UHG, 4UI6, 5BXO, 4UI8
Identifiers
Aliases	TNKS2, ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6, tankyrase 2
External IDs	OMIM: 607128; MGI: 1921743; HomoloGene: 11890; GeneCards: TNKS2; OMA:TNKS2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.32 Start 91,798,426 bp[1] End 91,865,475 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 36,811,632 bp[2] End 36,870,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii secondary oocyte triceps brachii muscle superior surface of tongue Epithelium of choroid plexus body of tongue mucosa of pharynx glutes superficial temporal artery Top expressed in primitive streak renal corpuscle tail of embryo aortic valve genital tubercle medullary collecting duct ascending aorta vestibular sensory epithelium retinal pigment epithelium urothelium More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity metal ion binding protein binding enzyme binding NAD+ ADP-ribosyltransferase activity protein ADP-ribosylase activity Cellular component cytoplasm cytosol Golgi apparatus pericentriolar material nuclear envelope membrane Golgi membrane chromosome telomere perinuclear region of cytoplasm nucleus Biological process protein auto-ADP-ribosylation protein ADP-ribosylation positive regulation of telomere capping multicellular organism growth regulation of multicellular organism growth positive regulation of canonical Wnt signaling pathway protein polyubiquitination positive regulation of telomere maintenance via telomerase protein localization to chromosome, telomeric region negative regulation of telomere maintenance via telomere lengthening Wnt signaling pathway protein poly-ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80351 74493 Ensembl ENSG00000107854 ENSMUSG00000024811 UniProt Q9H2K2 Q3UES3 RefSeq (mRNA) NM_025235 NM_001163635 RefSeq (protein) NP_079511 NP_001157107 Location (UCSC) Chr 10: 91.8 – 91.87 Mb Chr 19: 36.81 – 36.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TNKS2 has been shown to interact with GRB14,^[6] TERF1^[7][8][9] and Cystinyl aminopeptidase.^[8][9][10]