GRB14

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.^[5][6]

GRB14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AUG, 2AUH, 4K81
Identifiers
Aliases	GRB14, growth factor receptor bound protein 14
External IDs	OMIM: 601524; MGI: 1355324; HomoloGene: 3303; GeneCards: GRB14; OMA:GRB14 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.3 Start 164,492,417 bp[1] End 164,621,482 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 64,742,820 bp[2] End 64,855,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver corpus epididymis left adrenal cortex right adrenal gland right adrenal cortex right testis body of tongue renal medulla left testis body of pancreas Top expressed in interventricular septum vestibular membrane of cochlear duct myocardium of ventricle cardiac muscles right ventricle trigeminal ganglion atrium digastric muscle soleus muscle sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding identical protein binding protein homodimerization activity Cellular component cytoplasm cytosol endosome plasma membrane endosome membrane intracellular membrane-bounded organelle membrane Biological process positive regulation of signal transduction leukocyte migration signal transduction negative regulation of insulin receptor signaling pathway insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2888 50915 Ensembl ENSG00000115290 ENSMUSG00000026888 UniProt Q14449 Q9JLM9 RefSeq (mRNA) NM_001303422 NM_004490 NM_016719 RefSeq (protein) NP_001290351 NP_004481 NP_057928 Location (UCSC) Chr 2: 164.49 – 164.62 Mb Chr 2: 64.74 – 64.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.^[6]

Interactions

GRB14 has been shown to interact with Epidermal growth factor receptor,^[7] Fibroblast growth factor receptor 1^[8] and TNKS2.^[9]