TNRC6B

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.^[5]

TNRC6B
Identifiers
Aliases	TNRC6B, trinucleotide repeat containing 6B, trinucleotide repeat containing adaptor 6B, GDSBA
External IDs	OMIM: 610740; MGI: 2443730; HomoloGene: 66194; GeneCards: TNRC6B; OMA:TNRC6B - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 40,044,817 bp[1] End 40,335,808 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 80,595,514 bp[2] End 80,825,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell epithelium of nasopharynx sural nerve oocyte caput epididymis trabecular bone secondary oocyte seminal vesicula nipple tail of epididymis Top expressed in zygote secondary oocyte granulocyte genital tubercle tibiofemoral joint tail of embryo neural layer of retina human fetus lens inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component cytoplasm cytosol P-body nucleoplasm Biological process RNA interference positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of translation positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay gene silencing miRNA-mediated gene silencing by inhibition of translation Wnt signaling pathway, calcium modulating pathway regulation of megakaryocyte differentiation positive regulation of gene expression negative regulation of gene expression gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23112 213988 Ensembl ENSG00000100354 ENSMUSG00000047888 UniProt Q9UPQ9 Q8BKI2 RefSeq (mRNA) NM_015088 NM_001024843 NM_001162501 NM_144812 NM_177124 RefSeq (protein) NP_001020014 NP_001155973 NP_055903 NP_659061 NP_796098 Location (UCSC) Chr 22: 40.04 – 40.34 Mb Chr 15: 80.6 – 80.83 Mb PubMed search [3] [4]
Wikidata
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Interactions

TNRC6B has been shown to interact with EIF2C2.^[6] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.^[7]