TOB2

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.^[5][6][7][8]

TOB2
Identifiers
Aliases	TOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396; MGI: 1888525; HomoloGene: 9447; GeneCards: TOB2; OMA:TOB2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,433,494 bp[1] End 41,446,801 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 81,732,473 bp[2] End 81,742,997 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve paraflocculus of cerebellum gastric mucosa mucosa of paranasal sinus muscle of thigh popliteal artery tibial arteries gastrocnemius muscle right hemisphere of cerebellum Skeletal muscle tissue of rectus abdominis Top expressed in ascending aorta aortic valve retinal pigment epithelium ciliary body neural layer of retina brown adipose tissue epithelium of lens medial head of gastrocnemius muscle primary oocyte masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding vitamin D receptor binding transcription corepressor activity Cellular component nucleus cytoplasm cytosol Biological process positive regulation of ossification female gamete generation negative regulation of osteoclast differentiation regulation of gene expression negative regulation of cell population proliferation signaling negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10766 57259 Ensembl ENSG00000183864 ENSMUSG00000048546 UniProt Q14106 Q9JM55 RefSeq (mRNA) NM_016272 NM_020507 RefSeq (protein) NP_057356 NP_065253 Location (UCSC) Chr 22: 41.43 – 41.45 Mb Chr 15: 81.73 – 81.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM]^[7]

Interactions

TOB2 has been shown to interact with CNOT7.^[5]