TOMM20

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene.^[5][6][7][8] TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

TOMM20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4APO
Identifiers
Aliases	TOMM20, MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20
External IDs	OMIM: 601848; MGI: 1915202; HomoloGene: 44649; GeneCards: TOMM20; OMA:TOMM20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.3 Start 235,109,341 bp[1] End 235,128,837 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E2 Start 127,657,417 bp[2] End 127,672,594 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland skin of thigh Brodmann area 10 frontal pole skin of hip middle frontal gyrus caput epididymis lateral nuclear group of thalamus corpus epididymis pons Top expressed in yolk sac embryo embryo olfactory tubercle nucleus accumbens superior frontal gyrus subiculum ventromedial nucleus temporal lobe dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-transporting ATPase activity protein binding mitochondrion targeting sequence binding unfolded protein binding protein transmembrane transporter activity Cellular component integral component of membrane mitochondria associated membranes membrane mitochondrial outer membrane translocase complex integral component of mitochondrial outer membrane mitochondrial outer membrane mitochondrion mitochondrial envelope Biological process protein targeting tRNA import into mitochondrion mitochondrial outer membrane translocase complex assembly protein import into mitochondrial matrix protein transport intracellular protein transport protein targeting to mitochondrion protein deubiquitination response to muscle activity response to 3,3',5-triiodo-L-thyronine macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9804 67952 Ensembl ENSG00000173726 ENSMUSG00000093904 UniProt Q15388 Q9DCC8 RefSeq (mRNA) NM_014765 NM_024214 RefSeq (protein) NP_055580 NP_055580.1 NP_077176 Location (UCSC) Chr 1: 235.11 – 235.13 Mb Chr 8: 127.66 – 127.67 Mb PubMed search [3] [4]
Wikidata
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Function

In mitochondrial protein import, TOM20 is closely associated with the pore-forming TOM40 complex and acts by recognizing and binding the N-terminal MTSs (matrix-targeting sequences), which form an amphipathic alpha helix and aid passage of the target proteins into the mitochondrial matrix.^[9]

See also

• TOMM22
• TOMM40
• TOMM70A