TONSL

Tonsoku-like, DNA repair protein is a protein that in humans is encoded by the TONSL gene.^[5]

TONSL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JA4
Identifiers
Aliases	TONSL, IKBR, NFKBIL2, tonsoku-like, DNA repair protein, tonsoku like, DNA repair protein, SEMDSP
External IDs	OMIM: 604546; MGI: 1919999; HomoloGene: 22754; GeneCards: TONSL; OMA:TONSL - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,428,775 bp[1] End 144,444,440 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,510,202 bp[2] End 76,524,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon gonad ventricular zone ganglionic eminence granulocyte stromal cell of endometrium right adrenal gland apex of heart right adrenal cortex body of stomach Top expressed in internal carotid artery external carotid artery spermatocyte hand yolk sac spermatid gray matter layer of cerebellum epiblast primary oocyte submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function histone binding protein binding transcription corepressor activity Cellular component cytoplasm DNA replication factor A complex nuclear replication fork MCM complex nucleus FACT complex nucleoplasm nuclear body Biological process cytoplasmic sequestering of transcription factor double-strand break repair via homologous recombination replication fork processing DNA repair cellular response to DNA damage stimulus negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4796 72749 Ensembl ENSG00000160949 ENSMUSG00000059323 UniProt Q96HA7 Q6NZL6 RefSeq (mRNA) NM_013432 NM_183091 RefSeq (protein) NP_038460 NP_898914 Location (UCSC) Chr 8: 144.43 – 144.44 Mb Chr 15: 76.51 – 76.52 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.