TOPORS

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.^[4][5][6][7]

TOPORS
Identifiers
Aliases	TOPORS, LUN, P53BP3, RP31, TP53BPL, TOP1 binding arginine/serine rich protein, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
External IDs	OMIM: 609507; MGI: 2146189; HomoloGene: 4237; GeneCards: TOPORS; OMA:TOPORS - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse)[1] Band 4|4 A5 Start 40,259,601 bp[1] End 40,269,850 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sperm corpus epididymis caput epididymis trabecular bone jejunal mucosa seminal vesicula oral cavity bone marrow Top expressed in primitive streak maxillary prominence mandibular prominence hand medial ganglionic eminence Gonadal ridge endothelial cell of lymphatic vessel left lung lobe dermis seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding DNA binding SUMO transferase activity ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity DNA topoisomerase binding protein binding transferase activity Cellular component ciliary basal body PML body nuclear speck spindle pole ubiquitin ligase complex gamma-tubulin complex photoreceptor connecting cilium midbody cytoplasmic dynein complex centriole nucleus nucleoplasm Biological process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator retina layer formation ubiquitin-dependent protein catabolic process protein polyubiquitination negative regulation of apoptotic process retinal cone cell development protein monoubiquitination photoreceptor cell outer segment organization protein sumoylation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated protein K48-linked ubiquitination regulation of cell population proliferation positive regulation of ubiquitin-protein transferase activity retinal rod cell development intrinsic apoptotic signaling pathway in response to DNA damage protein localization to nucleus maintenance of protein location in nucleus proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10210 106021 Ensembl n/a ENSMUSG00000036822 UniProt Q9NS56 Q80Z37 RefSeq (mRNA) NM_005802 NM_001195622 NM_134097 RefSeq (protein) NP_001182551 NP_005793 NP_598858 Location (UCSC) n/a Chr 4: 40.26 – 40.27 Mb PubMed search [2] [3]
Wikidata
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