TP53INP1

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.^[5][6][7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein".

TP53INP1
Identifiers
Aliases	TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1, tumor protein p53 inducible nuclear protein 1
External IDs	OMIM: 606185; MGI: 1926609; HomoloGene: 11065; GeneCards: TP53INP1; OMA:TP53INP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 94,925,972 bp[1] End 94,949,378 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 11,156,431 bp[2] End 11,174,379 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm epithelium of nasopharynx thymus bronchial epithelial cell mucosa of ileum body of pancreas visceral pleura parietal pleura germinal epithelium palpebral conjunctiva Top expressed in stroma of bone marrow lymph node thymus mesenteric lymph nodes Paneth cell vestibular membrane of cochlear duct ascending aorta utricle blood pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antioxidant activity protein binding Cellular component cytosol PML body autophagosome cytoplasmic vesicle nucleus nucleoplasm cytoplasm Biological process regulation of transcription, DNA-templated cellular response to ethanol positive regulation of autophagy cellular response to methyl methanesulfonate cellular response to UV cellular oxidant detoxification positive regulation of apoptotic signaling pathway response to heat autophagosome assembly transcription, DNA-templated cellular response to hydroperoxide positive regulation of transcription, DNA-templated autophagy negative regulation of cell migration regulation of autophagy positive regulation of apoptotic process autophagic cell death negative regulation of cell population proliferation apoptotic process regulation of apoptotic process regulation of signal transduction by p53 class mediator positive regulation of gene expression negative regulation of gene expression negative regulation of fibroblast proliferation negative regulation of myofibroblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94241 60599 Ensembl ENSG00000164938 ENSMUSG00000028211 UniProt Q96A56 Q9QXE4 RefSeq (mRNA) NM_001135733 NM_033285 NM_001199105 NM_021897 RefSeq (protein) NP_001129205 NP_150601 NP_001186034 NP_068697 Location (UCSC) Chr 8: 94.93 – 94.95 Mb Chr 4: 11.16 – 11.17 Mb PubMed search [3] [4]
Wikidata
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Interactions

TP53INP1 has been shown to interact with HIPK2^[8] and p53.^[5][8]