TP53RK

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.^[5][6][7] This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

TP53RK
Identifiers
Aliases	TP53RK, BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB
External IDs	OMIM: 608679; MGI: 1914050; HomoloGene: 6042; GeneCards: TP53RK; OMA:TP53RK - orthologs
EC number	3.6.-.-
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,684,365 bp[1] End 46,689,444 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 166,634,451 bp[2] End 166,641,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence islet of Langerhans bronchial epithelial cell stromal cell of endometrium gonad cartilage tissue olfactory zone of nasal mucosa right adrenal cortex epithelium of nasopharynx Top expressed in spermatid female urethra embryo granulocyte embryo lumbar spinal ganglion primitive streak stroma of kidney epiblast yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity p53 binding protein binding ATP binding hydrolase activity phosphotransferase activity, alcohol group as acceptor protein serine/threonine kinase activity Cellular component cytosol membrane nucleus nucleoplasm EKC/KEOPS complex cytoplasm Biological process protein phosphorylation phosphorylation tRNA threonylcarbamoyladenosine metabolic process tRNA processing regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112858 76367 Ensembl ENSG00000172315 ENSMUSG00000042854 UniProt Q96S44 Q99PW4 RefSeq (mRNA) NM_033550 NM_023815 RefSeq (protein) NP_291028 NP_076304.2 Location (UCSC) Chr 20: 46.68 – 46.69 Mb Chr 2: 166.63 – 166.64 Mb PubMed search [3] [4]
Wikidata
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PRPK is part of the KEOPS/EKC complex, which participates in transcription control,^[8] telomere regulation ^[9] and tRNA modification.^[10]