TPCN1

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene.^[5] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).^[6][7][8]

TPCN1
Identifiers
Aliases	TPCN1, TPC1, two pore segment channel 1
External IDs	OMIM: 609666; MGI: 2182472; HomoloGene: 9905; GeneCards: TPCN1; OMA:TPCN1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 113,221,050 bp[1] End 113,298,585 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 120,672,218 bp[2] End 120,726,738 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right lobe of thyroid gland left lobe of thyroid gland gastric mucosa apex of heart right adrenal gland right adrenal cortex body of pancreas left adrenal cortex left ovary Top expressed in lacrimal gland saccule otic vesicle yolk sac aortic valve ankle intestinal villus molar ascending aorta submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity voltage-gated ion channel activity ion channel activity protein binding identical protein binding NAADP-sensitive calcium-release channel activity voltage-gated calcium channel activity calcium activated cation channel activity Cellular component integral component of membrane endosome membrane plasma membrane lysosomal membrane lysosome endosome membrane CatSper complex Biological process membrane depolarization during action potential positive regulation of autophagy regulation of ion transmembrane transport ion transport ion transmembrane transport calcium ion transmembrane transport calcium ion transport transmembrane transport release of sequestered calcium ion into cytosol flagellated sperm motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53373 252972 Ensembl ENSG00000186815 ENSMUSG00000032741 UniProt Q9ULQ1 Q9EQJ0 RefSeq (mRNA) NM_001143819 NM_001301214 NM_017901 NM_001351346 NM_001351347 NM_145853 RefSeq (protein) NP_001137291 NP_001288143 NP_060371 NP_001338275 NP_001338276 NP_665852 Location (UCSC) Chr 12: 113.22 – 113.3 Mb Chr 5: 120.67 – 120.73 Mb PubMed search [3] [4]
Wikidata
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Structure

The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.^[9][10] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands. Only a single voltage sensor domain appears to responsible for voltage sensing.

Filoviral infections

Genetic knockout and pharmacological inhibition experiments demonstrate that the two-pore channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.^[11]

See also

• Two-pore channel