TPCN2

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene.^[5] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).^[6]

TPCN2
Identifiers
Aliases	TPCN2, SHEP10, TPC2, two pore segment channel 2
External IDs	OMIM: 612163; MGI: 2385297; HomoloGene: 16375; GeneCards: TPCN2; OMA:TPCN2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.3 Start 69,048,932 bp[1] End 69,136,316 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 144,740,261 bp[2] End 144,837,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of ileum gastric mucosa muscle layer of sigmoid colon body of uterus monocyte right hemisphere of cerebellum tibialis anterior muscle left uterine tube right lobe of liver Top expressed in granulocyte inner renal medulla stroma of bone marrow lip ventricular zone spermatid yolk sac embryo blastocyst embryo More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity voltage-gated ion channel activity ion channel activity protein binding identical protein binding protein kinase binding NAADP-sensitive calcium-release channel activity voltage-gated calcium channel activity Cellular component integral component of membrane membrane plasma membrane endosome membrane lysosome lysosomal membrane Biological process release of sequestered calcium ion into cytosol membrane depolarization during action potential response to vitamin D regulation of ion transmembrane transport cellular calcium ion homeostasis ion transport ion transmembrane transport regulation of autophagy calcium ion transmembrane transport lysosome organization calcium-mediated signaling calcium ion transport transmembrane transport smooth muscle contraction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219931 233979 Ensembl ENSG00000162341 ENSMUSG00000048677 UniProt Q8NHX9 Q8BWC0 RefSeq (mRNA) NM_139075 NM_146206 RefSeq (protein) NP_620714 NP_666318 Location (UCSC) Chr 11: 69.05 – 69.14 Mb Chr 7: 144.74 – 144.84 Mb PubMed search [3] [4]
Wikidata
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Structure

TPC2 is homologous to TPC1, the best characterized member of the TPC family. The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.^[7][8] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands.

Filoviral infections

Genetic knockout and pharmacological inhibition experiments demonstrate that the two-pore channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.^[9]

See also

• Two-pore channel