TPD52L2

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.^[5][6]

TPD52L2
Identifiers
Aliases	TPD52L2, D54, TPD54, tumor protein D52 like 2, TPD52 like 2
External IDs	OMIM: 603747; MGI: 1913564; HomoloGene: 2469; GeneCards: TPD52L2; OMA:TPD52L2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,865,228 bp[1] End 63,891,545 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,138,935 bp[2] End 181,159,759 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery ascending aorta popliteal artery tibial arteries stromal cell of endometrium Descending thoracic aorta gastric mucosa left coronary artery smooth muscle tissue ectocervix Top expressed in saccule otic placode morula genital tubercle secondary oocyte zygote tail of embryo blastocyst condyle otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity protein heterodimerization activity RNA binding catalytic activity Cellular component cytoplasm perinuclear region of cytoplasm Biological process regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7165 66314 Ensembl ENSG00000101150 ENSMUSG00000000827 UniProt O43399 Q6FGS1 Q9CYZ2 RefSeq (mRNA) NM_001243891 NM_001243892 NM_001243894 NM_001243895 NM_003288 NM_199359 NM_199360 NM_199361 NM_199362 NM_199363 NM_001291197 NM_001291200 NM_001291201 NM_001291202 NM_001291203 NM_001291204 NM_025482 NM_001373959 NM_001373960 NM_001373961 RefSeq (protein) NP_001230820 NP_001230821 NP_001230823 NP_001230824 NP_003279 NP_955391 NP_955392 NP_955393 NP_955394 NP_955395 NP_003279.2 NP_001278126 NP_001278129 NP_001278130 NP_001278131 NP_001278132 NP_001278133 NP_079758 NP_001360888 NP_001360889 NP_001360890 NP_001393282 NP_001393283 NP_001393284 NP_001393285 NP_001393286 NP_001393287 NP_001393288 NP_001393289 NP_001393290 NP_001393291 NP_001393292 Location (UCSC) Chr 20: 63.87 – 63.89 Mb Chr 2: 181.14 – 181.16 Mb PubMed search [3] [4]
Wikidata
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Interactions

TPD52L2 has been shown to interact with TPD52L1^[5] and TPD52.^[5]

Cellular function

TPD52L2 has a role in membrane traffic.^[7] TPD52L2 is found on small transport vesicles, termed intracellular nanovesicles, that transfer proteins between different cellular compartments. When TPD52L2 is depleted from HeLa cells, the following trafficking pathways are impaired: anterograde traffic, recycling of cargo and Golgi integrity.^[7] Proteomic analysis indicates that TPD52L2 is one of the most abundant proteins expressed in HeLa cells.^[8]