TPM4

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.^[5][6]

TPM4
Identifiers
Aliases	TPM4, HEL-S-108, tropomyosin 4
External IDs	OMIM: 600317; MGI: 2449202; HomoloGene: 100849; GeneCards: TPM4; OMA:TPM4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12-p13.11 Start 16,067,021 bp[1] End 16,103,002 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 72,884,018 bp[2] End 72,906,986 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii stromal cell of endometrium right coronary artery gallbladder ascending aorta body of uterus left uterine tube smooth muscle tissue Descending thoracic aorta tibial arteries Top expressed in genital tubercle tail of embryo umbilical cord left lung lobe mandibular prominence maxillary prominence dermis endothelial cell of lymphatic vessel vas deferens abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding actin binding structural constituent of muscle protein binding metal ion binding identical protein binding protein homodimerization activity protein heterodimerization activity actin filament binding Cellular component cytoplasm filamentous actin podosome cytosol muscle thin filament tropomyosin cortical cytoskeleton extracellular exosome cytoskeleton membrane stress fiber focal adhesion actin filament actin cytoskeleton Biological process osteoblast differentiation muscle filament sliding muscle contraction actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7171 326618 Ensembl ENSG00000167460 ENSMUSG00000031799 UniProt P67936 Q6IRU2 RefSeq (mRNA) NM_001145160 NM_003290 NM_001367836 NM_001367837 NM_001367838 NM_001001491 RefSeq (protein) NP_001138632 NP_003281 NP_001354765 NP_001354766 NP_001354767 NP_001001491 Location (UCSC) Chr 19: 16.07 – 16.1 Mb Chr 8: 72.88 – 72.91 Mb PubMed search [3] [4]
Wikidata
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