TPPP

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.^{[5][6][7][8][9]}

TPPP
Identifiers
Aliases	TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs	OMIM: 608773; MGI: 1920198; HomoloGene: 21389; GeneCards: TPPP; OMA:TPPP - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 659,862 bp[1] End 693,352 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 74,157,526 bp[2] End 74,183,872 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus postcentral gyrus internal globus pallidus entorhinal cortex inferior ganglion of vagus nerve superior frontal gyrus ventral tegmental area superior vestibular nucleus subthalamic nucleus Top expressed in primary motor cortex ventral tegmental area cingulate gyrus piriform cortex dentate gyrus dentate gyrus of hippocampal formation granule cell superior colliculus lateral hypothalamus subiculum suprachiasmatic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding tubulin binding Cellular component cytoplasm perinuclear region of cytoplasm myelin sheath microtubule cytoskeleton nucleus mitochondrion cytosol microtubule bundle Biological process microtubule polymerization positive regulation of protein-containing complex assembly positive regulation of protein polymerization microtubule bundle formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11076 72948 Ensembl ENSG00000171368 ENSMUSG00000021573 UniProt O94811 Q7TQD2 RefSeq (mRNA) NM_007030 NM_182839 RefSeq (protein) NP_008961 NP_878259 Location (UCSC) Chr 5: 0.66 – 0.69 Mb Chr 13: 74.16 – 74.18 Mb PubMed search [3] [4]
Wikidata
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This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.^[10]

This has also been linked to Parkinson's and Alzheimer's Disease^[11][12]