TRA2A

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.^[5][6][7]

TRA2A
Identifiers
Aliases	TRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718; MGI: 1933972; HomoloGene: 40866; GeneCards: TRA2A; OMA:TRA2A - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 23,504,780 bp[1] End 23,532,041 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.3 Start 49,220,858 bp[2] End 49,240,967 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube buccal mucosa cell right ovary ganglionic eminence left ovary ventricular zone canal of the cervix sural nerve body of uterus right lobe of thyroid gland Top expressed in pineal gland Gonadal ridge abdominal wall maxillary prominence mandibular prominence tail of embryo dermis superior cervical ganglion epiblast ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding Cellular component nucleolus intracellular membrane-bounded organelle nucleus ribonucleoprotein complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29896 101214 Ensembl ENSG00000164548 ENSMUSG00000029817 UniProt Q13595 Q6PFR5 RefSeq (mRNA) NM_001282757 NM_001282758 NM_001282759 NM_013293 NM_001362759 NM_001362760 NM_001362761 NM_198102 NM_001347209 NM_001362188 RefSeq (protein) NP_001269686 NP_001269687 NP_001269688 NP_037425 NP_001349688 NP_001349689 NP_001349690 n/a Location (UCSC) Chr 7: 23.5 – 23.53 Mb Chr 6: 49.22 – 49.24 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.^[7]