TRAF5

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.^[5]

TRAF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GJH
Identifiers
Aliases	TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5
External IDs	OMIM: 602356; MGI: 107548; HomoloGene: 27079; GeneCards: TRAF5; OMA:TRAF5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 211,326,615 bp[1] End 211,374,946 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 97.11 cM Start 191,729,166 bp[2] End 191,776,868 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein body of pancreas superficial temporal artery lymph node gastric mucosa ascending aorta right coronary artery left uterine tube Descending thoracic aorta Epithelium of choroid plexus Top expressed in spleen urinary bladder neural layer of retina bone marrow granulocyte proximal tubule lung esophagus islet of Langerhans zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thioesterase binding zinc ion binding protein binding ubiquitin protein ligase binding metal ion binding identical protein binding tumor necrosis factor receptor binding Cellular component cytosol cytoplasmic side of plasma membrane centrosome CD40 receptor complex cytoplasm protein-containing complex Biological process regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity signal transduction apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7188 22033 Ensembl ENSG00000082512 ENSMUSG00000026637 UniProt O00463 P70191 RefSeq (mRNA) NM_001033910 NM_004619 NM_145759 NM_001319207 NM_011633 RefSeq (protein) NP_001029082 NP_001306136 NP_004610 NP_665702 NP_035763 Location (UCSC) Chr 1: 211.33 – 211.37 Mb Chr 1: 191.73 – 191.78 Mb PubMed search [3] [4]
Wikidata
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Function

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.^[6]

Interactions

TRAF5 has been shown to interact with:

• ASK1,^[7][8]
• CD134,^[9]
• CD30,^[10]
• CD40,^[11][12]
• RANK^[13][14][15]
• TNFRSF13B,^[16] and
• TNFRSF14.^[17][18]