TRAM2

Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.^[5][6][7]

TRAM2
Identifiers
Aliases	TRAM2, translocation associated membrane protein 2
External IDs	OMIM: 608485; MGI: 1924817; HomoloGene: 8183; GeneCards: TRAM2; OMA:TRAM2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.2 Start 52,497,408 bp[1] End 52,577,060 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A4 Start 21,066,523 bp[2] End 21,149,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte stromal cell of endometrium placenta cartilage tissue tibia synovial membrane synovial joint mucosa of ileum visceral pleura Top expressed in ascending aorta aortic valve cumulus cell calvaria body of femur mesenteric lymph nodes umbilical cord endothelial cell of lymphatic vessel tail of embryo ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane rough endoplasmic reticulum Biological process protein transport collagen biosynthetic process protein insertion into ER membrane SRP-dependent cotranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9697 170829 Ensembl ENSG00000065308 ENSMUSG00000041779 UniProt Q15035 Q924Z5 RefSeq (mRNA) NM_012288 NM_177409 RefSeq (protein) NP_036420 NP_803128 Location (UCSC) Chr 6: 52.5 – 52.58 Mb Chr 1: 21.07 – 21.15 Mb PubMed search [3] [4]
Wikidata
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TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.^[7]