TRAP1

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.^[5][6][7]

TRAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z1F, 4Z1G, 4Z1H, 4Z1I, 5F3K, 5F5R
Identifiers
Aliases	TRAP1, HSP 75, HSP75, HSP90L, TRAP-1, TNF receptor associated protein 1
External IDs	OMIM: 606219; MGI: 1915265; HomoloGene: 9457; GeneCards: TRAP1; OMA:TRAP1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,651,639 bp[1] End 3,717,553 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.38 cM Start 3,857,835 bp[2] End 3,895,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right uterine tube gastrocnemius muscle triceps brachii muscle glutes right lobe of liver body of pancreas apex of heart skin of leg skin of abdomen Top expressed in right kidney Paneth cell muscle of thigh masseter muscle proximal tubule skeletal muscle tissue brown adipose tissue fetal liver hematopoietic progenitor cell human kidney sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding unfolded protein binding protein binding tumor necrosis factor receptor binding ATP binding protein kinase binding RNA binding Cellular component membrane mitochondrial intermembrane space lipid droplet nucleoplasm mitochondrial matrix mitochondrion mitochondrial inner membrane extracellular exosome Biological process response to stress negative regulation of cellular respiration protein folding negative regulation of reactive oxygen species biosynthetic process translational attenuation chaperone-mediated protein folding negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10131 68015 Ensembl ENSG00000126602 ENSMUSG00000005981 UniProt Q12931 Q9CQN1 RefSeq (mRNA) NM_001272049 NM_016292 NM_026508 RefSeq (protein) NP_001258978 NP_057376 NP_080784 Location (UCSC) Chr 16: 3.65 – 3.72 Mb Chr 16: 3.86 – 3.9 Mb PubMed search [3] [4]
Wikidata
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Interactions

TRAP1 has been shown to interact with EXT2,^[8] EXT1^[8] and Retinoblastoma protein.^[9]