TRIM33

E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.^{[5] [6]}

TRIM33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U5M, 3U5N, 3U5O, 3U5P
Identifiers
Aliases	TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
External IDs	OMIM: 605769; MGI: 2137357; HomoloGene: 9296; GeneCards: TRIM33; OMA:TRIM33 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 114,392,790 bp[1] End 114,511,203 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 103,186,609 bp[2] End 103,266,091 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Epithelium of choroid plexus Brodmann area 23 corpus epididymis nipple cerebellar vermis tibia Region I of hippocampus proper epithelium of nasopharynx seminal vesicula Top expressed in genital tubercle primitive streak tail of embryo ciliary body zygote trigeminal ganglion iris Epithelium of choroid plexus retinal pigment epithelium secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding R-SMAD binding co-SMAD binding zinc ion binding metal ion binding ubiquitin-protein transferase activity protein binding transferase activity Cellular component intracellular anatomical structure nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway protein ubiquitination negative regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51592 94093 Ensembl ENSG00000197323 ENSMUSG00000033014 UniProt Q9UPN9 Q99PP7 RefSeq (mRNA) NM_015906 NM_033020 NM_001079830 NM_053170 RefSeq (protein) NP_056990 NP_148980 NP_001073299 NP_444400 Location (UCSC) Chr 1: 114.39 – 114.51 Mb Chr 3: 103.19 – 103.27 Mb PubMed search [3] [4]
Wikidata
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TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.^[7]

Structure

The protein is a member of the tripartite motif family.^[8] This motif includes three zinc-binding domains:

• RING
• B-box type 1 zinc finger
• B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.^[7]

Interactions

TRIM33 has been shown to interact with TRIM24.^[9]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.^[10] TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. ^[11] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.^[12]