TRIOBP

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.^[5][6][7][8]

TRIOBP
Identifiers
Aliases	TRIOBP, DFNB28, TAP68, TARA, dJ37E16.4, HRIHFB2122, TRIO and F-actin binding protein
External IDs	OMIM: 609761; MGI: 1349410; HomoloGene: 5104; GeneCards: TRIOBP; OMA:TRIOBP - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,697,048 bp[1] End 37,776,556 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.7 cM Start 78,831,924 bp[2] End 78,890,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung apex of heart right ventricle stromal cell of endometrium tail of epididymis tendon of biceps brachii left uterine tube ectocervix canal of the cervix right coronary artery Top expressed in zygote granulocyte genital tubercle tail of embryo tibiofemoral joint secondary oocyte triceps brachii muscle external carotid artery lip ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding actin binding ubiquitin protein ligase binding myosin II binding Cellular component focal adhesion microtubule organizing center nucleus cytoskeleton midbody actin cytoskeleton cytoplasm Biological process barbed-end actin filament capping regulation of actin cytoskeleton organization cell cycle cell division positive regulation of substrate adhesion-dependent cell spreading actin modification hearing auditory receptor cell stereocilium organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11078 110253 Ensembl ENSG00000100106 ENSMUSG00000033088 UniProt Q9H2D6 Q99KW3 RefSeq (mRNA) NM_138632 NM_001039141 NM_007032 NM_001024716 NM_001039155 NM_001039156 NM_138579 RefSeq (protein) NP_001034230 NP_008963 NP_619538 NP_001019887 NP_001034244 NP_001034245 NP_613045 Location (UCSC) Chr 22: 37.7 – 37.78 Mb Chr 15: 78.83 – 78.89 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessive nonsyndromic deafness. Multiple alternatively-spliced transcript variants that would encode different isoforms have been found for this gene, though some transcripts may be subject to nonsense-mediated decay (NMD).^[8]