TRIP12

Probable E3 ubiquitin-protein ligase TRIP12 is an enzyme that in humans is encoded by the TRIP12 gene.^[4][5]

TRIP12
Identifiers
Aliases	TRIP12, TRIP-12, ULF, thyroid hormone receptor interactor 12
External IDs	OMIM: 604506; MGI: 1309481; HomoloGene: 44226; GeneCards: TRIP12; OMA:TRIP12 - orthologs
Gene location (Mouse) Chr. Chromosome 1 (mouse)[1] Band 1|1 C5 Start 84,721,189 bp[1] End 84,840,516 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in spermatid spermatocyte seminiferous tubule Gonadal ridge primitive streak medullary collecting duct hair follicle conjunctival fornix primary oocyte urothelium BioGPS More reference expression data
Gene ontology Molecular function thyroid hormone receptor binding protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component nucleus nucleoplasm cytosol nuclear speck cytoplasm Biological process negative regulation of double-strand break repair negative regulation of histone H2A K63-linked ubiquitination DNA repair protein ubiquitination embryo development cellular response to DNA damage stimulus protein polyubiquitination ubiquitin-dependent protein catabolic process regulation of embryonic development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9320 14897 Ensembl ENSG00000153827 ENSMUSG00000026219 UniProt Q14669 G5E870 RefSeq (mRNA) NM_001284214 NM_001284215 NM_001284216 NM_004238 NM_133975 RefSeq (protein) NP_001271143 NP_001271144 NP_001271145 NP_004229 NP_001335244 NP_001335245 NP_001335246 NP_001335247 NP_001335248 NP_001335249 NP_001335250 NP_001335251 NP_001335252 NP_001335253 NP_001335254 NP_001335255 NP_001335256 NP_001335257 NP_001335258 NP_001335259 NP_001335260 NP_001335261 NP_001335262 NP_001335263 NP_001335264 NP_001335265 NP_598736 Location (UCSC) n/a Chr 1: 84.72 – 84.84 Mb PubMed search [2] [3]
Wikidata
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Interactions

TRIP12 has been shown to interact with APPBP1.^[6]