TRIP4

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.^[5][6]

TRIP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5O
Identifiers
Aliases	TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs	OMIM: 604501; MGI: 1928469; HomoloGene: 9426; GeneCards: TRIP4; OMA:TRIP4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 64,387,748 bp[1] End 64,455,303 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,736,212 bp[2] End 65,816,076 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve amniotic fluid mucosa of transverse colon jejunal mucosa monocyte gonad right lobe of thyroid gland left lobe of thyroid gland ganglionic eminence anterior pituitary Top expressed in pineal gland granulocyte spermatocyte left lobe of liver zygote spermatid lumbar spinal ganglion secondary oocyte substantia nigra cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding transcription coactivator activity zinc ion binding estrogen receptor binding protein binding histone acetyltransferase binding nuclear receptor binding ubiquitin-like protein ligase binding metal ion binding protein kinase binding Cellular component cytoplasm cytosol cytoskeleton nucleus nucleoplasm microtubule organizing center neuromuscular junction nuclear body activating signal cointegrator 1 complex centrosome protein-containing complex Biological process positive regulation of transcription, DNA-templated toxin transport intracellular estrogen receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of myoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9325 56404 Ensembl ENSG00000103671 ENSMUSG00000032386 UniProt Q15650 Q9QXN3 RefSeq (mRNA) NM_016213 NM_001321924 NM_001170907 NM_019797 NM_001357872 RefSeq (protein) NP_001308853 NP_057297 NP_001164378 NP_062771 NP_001344801 Location (UCSC) Chr 15: 64.39 – 64.46 Mb Chr 9: 65.74 – 65.82 Mb PubMed search [3] [4]
Wikidata
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Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.^[7]