TRIT1

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

TRIT1
Identifiers
Aliases	TRIT1, IPT, MOD5, GRO1, IPPT, IPTase, hGRO1, tRNA isopentenyltransferase 1, COXPD35
External IDs	OMIM: 617840; MGI: 1914216; HomoloGene: 7010; GeneCards: TRIT1; OMA:TRIT1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 39,838,110 bp[1] End 39,883,511 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 122,910,390 bp[2] End 122,948,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte body of pancreas skin of leg vagina skin of abdomen right uterine tube secondary oocyte left lobe of thyroid gland prostate body of uterus Top expressed in saccule medullary collecting duct otic vesicle renal corpuscle otic placode lacrimal gland hair follicle cumulus cell primary oocyte fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding metal ion binding tRNA dimethylallyltransferase activity nucleic acid binding zinc ion binding Cellular component cytoplasm mitochondrial matrix mitochondrion cellular component Biological process mitochondrial tRNA modification tRNA processing tRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54802 66966 Ensembl ENSG00000043514 ENSMUSG00000028653 UniProt Q9H3H1 Q80UN9 RefSeq (mRNA) NM_001312691 NM_001312692 NM_017646 NM_025873 RefSeq (protein) NP_001299620 NP_001299621 NP_060116 NP_080149 Location (UCSC) Chr 1: 39.84 – 39.88 Mb Chr 4: 122.91 – 122.95 Mb PubMed search [3] [4]
Wikidata
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It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.^[5][6][7]