TRMU

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.^[5][6]

TRMU
Identifiers
Aliases	TRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase, tRNA mitochondrial 2-thiouridylase
External IDs	OMIM: 610230; MGI: 1919276; HomoloGene: 5589; GeneCards: TRMU; OMA:TRMU - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 46,330,875 bp[1] End 46,357,340 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 85,763,513 bp[2] End 85,781,595 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum right uterine tube anterior pituitary right auricle of heart right lobe of thyroid gland body of pancreas ventricular zone left ovary right ovary Top expressed in neural layer of retina right kidney interventricular septum proximal tubule otolith organ neural tube lens utricle ventricular zone lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding transferase activity tRNA binding nucleotide binding sulfurtransferase activity ATP binding methyltransferase activity Cellular component mitochondrion nucleoplasm Biological process tRNA wobble position uridine thiolation mitochondrial tRNA thio-modification tRNA processing methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55687 72026 Ensembl ENSG00000100416 ENSMUSG00000022386 UniProt O75648 Q2PPL5 Q9DAT5 RefSeq (mRNA) NM_001008569 NM_001008571 NM_001282782 NM_001282783 NM_001282784 NM_001282785 NM_018006 NM_028063 RefSeq (protein) NP_001269711 NP_001269712 NP_001269713 NP_001269714 NP_060476 NP_001269711.1 NP_082339 Location (UCSC) Chr 22: 46.33 – 46.36 Mb Chr 15: 85.76 – 85.78 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.^[6]