TRNT1

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene.^[5][6][7] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.^[8]

TRNT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OU5, 4X4W
Identifiers
Aliases	TRNT1, CCA1, MtCCA, CGI-47, SIFD, tRNA nucleotidyl transferase 1, RPEM
External IDs	OMIM: 612907; MGI: 1917297; HomoloGene: 9333; GeneCards: TRNT1; OMA:TRNT1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.2 Start 3,126,916 bp[1] End 3,150,879 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E1 Start 106,746,081 bp[2] End 106,759,435 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte gonad Achilles tendon parietal pleura epithelium of colon pancreatic epithelial cell cartilage tissue metanephros testicle Top expressed in spermatocyte zygote spermatid genital tubercle secondary oocyte tail of embryo yolk sac ventricular zone embryo atrioventricular valve More reference expression data BioGPS n/a
Gene ontology Molecular function CTP:3'-cytidine-tRNA cytidylyltransferase activity transferase activity nucleotide binding tRNA binding nucleotidyltransferase activity ATP binding CTP:tRNA cytidylyltransferase activity RNA binding 5'-3' RNA polymerase activity ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity Cellular component mitochondrial matrix intracellular anatomical structure mitochondrion nucleoplasm Biological process RNA processing tRNA 3'-terminal CCA addition tRNA processing tRNA 3'-end processing mitochondrial tRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51095 70047 Ensembl ENSG00000072756 ENSMUSG00000013736 UniProt Q96Q11 Q8K1J6 RefSeq (mRNA) NM_001302946 NM_016000 NM_182916 NM_001242358 NM_001242360 NM_027296 RefSeq (protein) NP_001289875 NP_886552 NP_001354250 NP_001354251 NP_001354252 NP_001229287 NP_001229289 NP_081572 Location (UCSC) Chr 3: 3.13 – 3.15 Mb Chr 6: 106.75 – 106.76 Mb PubMed search [3] [4]
Wikidata
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