TRPM7

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

TRPM7
Identifiers
Aliases	TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDs	OMIM: 605692; MGI: 1929996; HomoloGene: 9774; GeneCards: TRPM7; OMA:TRPM7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 50,552,473 bp[1] End 50,686,797 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 126,633,485 bp[2] End 126,718,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle Achilles tendon cardiac muscle tissue of right atrium epithelium of colon sural nerve cartilage tissue testicle gastric mucosa right lobe of liver buccal mucosa cell Top expressed in molar Rostral migratory stream tail of embryo Gonadal ridge parotid gland saccule epithelium of small intestine pineal gland atrium genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding myosin binding metal ion binding kinase activity protein serine/threonine kinase activity ion channel activity actin binding ATP binding calcium channel activity Cellular component integral component of membrane membrane ruffle plasma membrane Biological process cellular magnesium ion homeostasis calcium-dependent cell-matrix adhesion programmed cell death phosphorylation actomyosin structure organization cation transport ion transport protein tetramerization protein phosphorylation calcium ion transmembrane transport protein autophosphorylation necroptosis calcium ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54822 58800 Ensembl ENSG00000092439 ENSMUSG00000027365 UniProt Q96QT4 Q923J1 RefSeq (mRNA) NM_001301212 NM_017672 NM_001164325 NM_021450 RefSeq (protein) NP_001288141 NP_060142 NP_001157797 NP_067425 Location (UCSC) Chr 15: 50.55 – 50.69 Mb Chr 2: 126.63 – 126.72 Mb PubMed search [3] [4]
Wikidata
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Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.^[5]

Interactions

TRPM7 has been shown to interact with PLCB1^[6] and PLCB2.^[6]

Clinical relevance

Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.^[7][8]

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.^[9]

See also

• TRPM